A novel chiral phosphinediamine ligand and asymmetric hydrogenation of acrylic acid derivatives

Article abstract of DOI:10.1016/S0957-4166(96)00437-5

A novel chiral phosphinediamine ligand (PN₂) was prepared from (S)-1-phenylethylamine and dichloroisopropylphosphine. The rhodium-PN₂ catalyst utilizing selective ligation of the amino unit and electrostatic interaction between the ligand and a substrate gave high enantioselectivities up to 92% ee in asymmetric hydrogenations of acrylic acid derivatives.