Synthetic entry into the ent-kaurene framework. Application of an unprecedented transannular cyclization for forming the central bond common to the B and C rings

Article abstract of DOI:10.1016/S0040-4039(96)02247-2

A stereocontrolled means for constructing the ent-kaurene framework is described. The key transformation involves transannular ring closure of an 8,9-seco precursor with migration of an interstitial methoxyl group.