Bioorganic and Medicinal Chemistry Letters p. 1157 - 1162 (1998)
Update date:2022-08-05
Topics:
Campbell, David A.
Xiao, Xiao-Yi
Harris, David
Ida, Satoru
Mortezaei, Reza
Ngu, Khehyong
Shi, Lihong
Tien, David
Wang, Yongwen
Navre, Marc
Patel, Dinesh V.
Sharr, Michele A.
DiJoseph, John F.
Killar, Loran M.
Leone, Christina L.
Levin, Jeremy I.
Skotnicki, Jerauld S.
A novel series of matrix metalloproteinase (MMP) inhibitors is described. Incorporation of a terminal α-mercaptoketone or α- mercaptoalcohol in the zinc binding domain of a series of inhibitors led to compounds exhibiting low nanomolar activity against collagenase-1 (MMP-1), stromelysin (MMP-3), and gelatinase-B (MMP-9).
View MoreContact:
Address:ROOM 1715, No#345 Jin Xiang Road, Pudong District
LinHai Cina Chemical Co., LTD.
Contact:0576-85580989
Address:Pharma-chem zone,Duqiao,Linhai,Zhejiang,China
Hebei Fulong Import & Export Co., Ltd.
Contact:86-311-87795661
Address:15A19 Zhongyuan Building,368 Youyi North Street,Shijiazhuang 050070,China
Shanghai Rich Chemicals Co., Ltd
website:http://www.richchemical.com
Contact:+86-21-20255798
Address:Pudong Shanghai,China
website:http://www.enbridgepharm.com
Contact:+86-510-83591909
Address:Huishan Zone, Wuxi City, Jiangsu Province, P.R.China
Doi:10.1111/cbdd.12319
(2014)Doi:10.1016/0022-328X(68)80072-5
(1968)Doi:10.1016/S0968-0896(96)00182-4
(1996)Doi:10.1039/a606575i
(1997)Doi:10.1021/jo962135m
(1997)Doi:10.1021/jo982154r
(1999)
