Bioorganic and Medicinal Chemistry Letters p. 1157 - 1162 (1998)
Update date:2022-08-05
Topics:
Campbell, David A.
Xiao, Xiao-Yi
Harris, David
Ida, Satoru
Mortezaei, Reza
Ngu, Khehyong
Shi, Lihong
Tien, David
Wang, Yongwen
Navre, Marc
Patel, Dinesh V.
Sharr, Michele A.
DiJoseph, John F.
Killar, Loran M.
Leone, Christina L.
Levin, Jeremy I.
Skotnicki, Jerauld S.
A novel series of matrix metalloproteinase (MMP) inhibitors is described. Incorporation of a terminal α-mercaptoketone or α- mercaptoalcohol in the zinc binding domain of a series of inhibitors led to compounds exhibiting low nanomolar activity against collagenase-1 (MMP-1), stromelysin (MMP-3), and gelatinase-B (MMP-9).
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