Enantioselective allylation of α-ketoester oximes with an external chiral ligand: Asymmetric synthesis of allylglycines and allylalanine

Article abstract of DOI:10.1016/S0040-4039(96)02112-0

A highly enantioselective allylation of oximes of α-ketoesters is described with phenyl substituted chiral bis(oxazoline) as external ligand of allylzinc reagents. This method provides an efficient and convenient access to N-benzyloxy allylglycine, allylglycine and chain substituted variants with high enantiomeric purities. Copyright (C) 1996 Elsevier Science Ltd.