Lipid A and related compounds. XXXI. Synthesis of biologically active N-acylated L-serine-containing D-glucosamine 4-phosphate derivatives of lipid A

DOI: 10.1248/cpb.44.2268

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 2268 - 2273 (1996)

Update date:2022-08-04

Topics:

Authors:

Miyajima, Keisuke

Ikeda, Kiyoshi

Achiwa, Kazuo

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Article abstract of DOI:10.1248/cpb.44.2268

New N-acylated L-serine-containing non-phosphorylated and phosphorylated D-glucosamine derivatives structurally corresponding to the lipid A disaccharide backbone were synthesized. Compounds 2, 4 and 5 exhibited potent mitogenic activity. Further, compound 5 showed nitric oxide (NO) productivity.

Full text of DOI:10.1248/cpb.44.2268

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