Synthesis of the C1-C9 segment of epothilons

DOI: 10.1016/S0040-4039(96)02493-8

Source and publish data:

Tetrahedron Letters p. 1359 - 1362 (1997)

Update date:2022-08-03

Topics:

Authors:

Claus, Eckhard

Pahl, Axel

Jones, Peter G.

Meyer, Hartmut M.

Kalesse, Markus

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Article abstract of DOI:10.1016/S0040-4039(96)02493-8

The C1-C9 segment of epothilons was generated by an aldol reaction between chiral aldehyde 3 and ethyl ketone 4. Removal of the TBS protecting groups and debenzylation generated spiro ketal 13 which was analyzed by X-ray crystallography.

Full text of DOI:10.1016/S0040-4039(96)02493-8

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