Synthesis of the C1-C9 segment of epothilons

DOI: 10.1016/S0040-4039(96)02493-8

Source and publish data:

Tetrahedron Letters p. 1359 - 1362 (1997)

Update date:2022-08-03

Topics:

Authors:

Claus, Eckhard

Pahl, Axel

Jones, Peter G.

Meyer, Hartmut M.

Kalesse, Markus

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(96)02493-8

The C1-C9 segment of epothilons was generated by an aldol reaction between chiral aldehyde 3 and ethyl ketone 4. Removal of the TBS protecting groups and debenzylation generated spiro ketal 13 which was analyzed by X-ray crystallography.

Full text of DOI:10.1016/S0040-4039(96)02493-8

Products guided by the article

Product name:[(S)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2,2-dimethyl-pentyloxymethyl]-benzene

Cas No:187527-29-3

R&D Labs maybe for 187527-29-3

shanghai payne pharm co.,ltd.

Contact:+86-021-58123769

Address:No.780 of Cailun Road,Zhangjiang Hi-tech Park,Pudong,Shanghai
shanghai tuomiao chemicial co.,ltd.

website:https://www.tuomiaochem.com/

Contact:021 - 59853336

Address:shanghai
MedicalChem(Yancheng)Manuf.Co.,Ltd.

Contact:+86-515-84383366

Address:Touzeng BinHai, YanCheng City, JiangSu Province, China
TLS PHARMACEUTICAL CO.,LTD

Contact:0833-5590788/5590338/5590055

Address:Victory in the town of Red Star Village,Mount Emei City,industrial concentration area storage processing logistics parkpark
Tianjin Hedong Red Cliff Chemical Reagent Factory

Contact:+86-022-84780548

Address:Li Ming Zhuang Gong Ye Yuan,Dongli District,Tianjin,China

Relevant to this article

Asymmetric synthesis of dideazafolate antitumor agents via amidomethylation of nonracemic oxazolidinone imidates, synthesis of LY309887, a cytotoxic dideazafolate analog related to lometrexol

Doi:10.1016/S0040-4039(96)02418-5
(1997)
Synthesis of 1,2,4-trioxanes and 1,2,4-trioxepanes by N-halogenosuccinimide-mediated cyclisations of unsaturated hydroperoxyacetals

Doi:10.1039/a605616d
(1997)
Synthesis and chemiluminescent property of the novel 1,2-Dioxetanes containing an acridane-10-acetate moiety as the luminophore and trigger unit

Doi:10.1016/S0040-4039(96)02463-X
(1997)
Synthesis and incorporation of carbocyclic nucleosides into a hammerhead ribozyme domain-RNase resistance and catalytic activity

Doi:10.1039/CC9960001623
(1996)
Novel tele nucleophilic aromatic substitutions in α-(benzotriazol-1-yl)alkyl aryl ketones

Doi:10.1016/S0040-4039(96)02455-0
(1997)
Multiple hindered rotators in a gyroscope-inspired tribenzylamine hemicryptophane

Doi:10.1021/jo102480s
(2011)

Article Doi