Studies toward funiculosin. Intramolecular carbonyl condensations using carboxamidimidazolide intermediates

Article abstract of DOI:10.1016/S0040-4039(96)02343-X

Internal enolate condensation, utilizing carboxamidimidazols as activated ureas, prove a general synthesis of the 3,5-disubstituted-4-hydroxy-2-pyridinone 2 as found in funiculosin. The novel all-syn-cyclitol, C-linked to the heterocyclic system, is prepared from croconic acid.