Bioorganic and Medicinal Chemistry Letters p. 1175 - 1180 (1998)
Update date:2022-09-26
Topics:
Girault, Sophie
Davioud-Charvet, Elisabeth
Salmon, Laurence
Berecibar, Amaya
Debreu, Marie-Ange
Sergheraert, Christian
In order to establish structural elements responsible for inhibition of trypanothione reductase (TR) from TrypanosoMa cruzi by 2- aminodiphenylsulfides, a series of dissymmetrical derivatives, corresponding to the replacement of one aromatic moiety by different amines, was synthesized. TR inhibition studies revealed the importance of the aromatic rings and of the amino groups in the side chains for potent inhibition. Quinonic moities were also introduced with the aim of acting as TR redox- cycling substrates.
View MoreContact:+86-025-52406782
Address:8 Taizishan Rd., Yanjiang Industrial Development Area, Nanjing, Jiangsu, China.
Compro Shijiazhuang Fine Chemical Co., Ltd
Contact:0086-311-89689838
Address:Economic and Technological Development Zone of Shijiazhuang,Hebei
Jintan City Mego Chemical Co., Ltd
Contact:+86-0519-82814387
Address:23# Dengguan Town, Jintan, Jiangsu Province, China
Beijing Zhongshuo Pharmaceutical T & D Co.,Ltd
Contact:0086-10-64430626
Address:ea No 16, HEPINGLI,DONGCHENG DISTRICT,BEIJING,P.R.CHINA.
Shuanghe Bio-Technology Limited(expird)
Contact:+86-571-61710758,18968016640
Address:Jinqiao north road 916# Fuyang
Doi:10.1016/S0040-4020(97)00309-8
(1997)Doi:10.1021/jo962165p
(1997)Doi:10.1016/0957-4166(96)00132-2
(1996)Doi:10.1021/om960703i
(1997)Doi:10.1021/jm990004i
(1999)Doi:10.1021/om9701377
(1997)
