
Tetrahedron Letters p. 615 - 618 (1997)
Update date:2022-08-03
Topics:
Kitagawa, Osamu
Fujita, Masao
Li, Hua
Taguchi, Takeo
A new and general method of iodine-mediated cyclization reactions of unsaturated carbamates, ureas and amides which gives N-cyclized products as a single regio-isomer was achieved. The present reaction proceeds in good yield through regio-control of an ambident nucleophile by LiAl(Ot-Bu)4, and the regio-control (N-attack vs O-attack) was also found to be remarkably affected by the additive employed.
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