
Tetrahedron p. 4339 - 4348 (1987)
Update date:2022-08-03
Topics:
Duhamel, L.
Duhamel, P.
Lecouve, J.P.
This new reagent is obtained by bromine-lithium exchange using tertiobutyllithium in ether at -70 deg C.Its condensation with carbonyl compounds followed by hydrolysis in mild conditions leads to polyenals with good yields.Synthesis of retinal from β-ionylidenacetaldehyde is described.
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(1962)