An expeditious synthesis of (2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol, a key building block of HIV protease inhibitors

Article abstract of DOI:10.1016/S0040-4039(96)02406-9

The title synthesis was achieved by the diastereoselective addition of an anion produced from N-nitroso-N-methylisobutylamine with (S)-2-N,N-dibenzylamino-3-phenylpropanal as a key step.