An expeditious synthesis of (2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol, a key building block of HIV protease inhibitors

DOI: 10.1016/S0040-4039(96)02406-9

Source and publish data:

Tetrahedron Letters p. 619 - 620 (1997)

Update date:2022-07-29

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Authors:

Shibata, Norio

Katoh, Tadashi

Terashima, Shiro

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Article abstract of DOI:10.1016/S0040-4039(96)02406-9

The title synthesis was achieved by the diastereoselective addition of an anion produced from N-nitroso-N-methylisobutylamine with (S)-2-N,N-dibenzylamino-3-phenylpropanal as a key step.

Full text of DOI:10.1016/S0040-4039(96)02406-9

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