Synthesis and antitumor activity of fused quinoline derivatives. IV. Novel 11-aminoindolo[3,2-b]quinolines

DOI: 10.1248/cpb.45.406

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 406 - 411 (1997)

Update date:2022-08-05

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Authors:

Takeuchi, Yasuo

Oda, Toshiaki

Chang, Ming-Rong

Okamoto, Yoko

Ono, Junko

Oda, Yoko

Harada, Kyoko

Hashigaki, Kuniko

Yamato, Masatoshi

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Article abstract of DOI:10.1248/cpb.45.406

Indolo[3,2-b]quinoline derivatives (1) having various amine moieties were prepared and their antitumor activities against P388 leukemia in mice were evaluated, for the purpose of gaining an insight into the role of the amine moiety in the antitumor activity and searching for an effective amine moiety. Introduction of a methylene group between the phenyl group and amino or methanesulfonamido group resulted in decrease or loss of activity.

Full text of DOI:10.1248/cpb.45.406

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