Chemical and Pharmaceutical Bulletin p. 406 - 411 (1997)
Update date:2022-08-05
Topics:
Takeuchi, Yasuo
Oda, Toshiaki
Chang, Ming-Rong
Okamoto, Yoko
Ono, Junko
Oda, Yoko
Harada, Kyoko
Hashigaki, Kuniko
Yamato, Masatoshi
Indolo[3,2-b]quinoline derivatives (1) having various amine moieties were prepared and their antitumor activities against P388 leukemia in mice were evaluated, for the purpose of gaining an insight into the role of the amine moiety in the antitumor activity and searching for an effective amine moiety. Introduction of a methylene group between the phenyl group and amino or methanesulfonamido group resulted in decrease or loss of activity.
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Doi:10.1016/S0040-4039(97)00424-3
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