Enzymatic coupling of α,α-dialkyl amino acids using inverse substrates as acyl donors

Article abstract of DOI:10.1016/S0040-4039(97)00167-6

Two series of inverse substrates, N(α)-Boc-α,α-dialkyl amino acid p-guanidino- and p-(guanidinomethyl)phenyl esters, were prepared as acyl donor components for enzymatic peptide synthesis. They were found to be readily coupled with amino acid p-nitroanili