Tetrahedron Letters p. 1987 - 1990 (1997)
Update date:2022-08-02
Topics:
Sakal, Takashi
Takayama, Tetsuo
Ohkawa, Takafumi
Yoshio, Osamu
Ema, Tadashi
Utaka, Masanori
Efficient kinetic resolution of racemic 3-hydroxy-3-(pentafluorophenyl)- propionitrile (±)-1 by a lipase-catalyzed transesterification gave optically pure (S)-3-hydroxy-3-(pentafluorophenyl-)propionitrile (S)-1 and (R)-(+)-3-acetoxy-3-(penta-fluorophenyl)propionitrile (R)-1 [>99% ee, respectively, E = 1057], the former of which was further transformed into (S)-(-)-3-amino-1-(pentafluorophenyl)-1-propanol (S)-7 in four steps.
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Doi:10.1016/S0040-4020(97)00129-4
(1997)Doi:10.1016/0022-328X(90)85398-I
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(1967)Doi:10.1039/c7ra00199a
(2017)Doi:10.1021/ic970030b
(1997)Doi:10.1039/j29690000495
(1969)
