Synthesis of enantiomerically pure desmethyl C,D-Ring derivative of paclitaxel (Taxo(TM)) via asymmetric Diels-Alder reaction of 2-siloxyfuran

DOI: 10.1016/S0040-4039(97)00454-1

Source and publish data:

Tetrahedron Letters p. 2725 - 2728 (1997)

Update date:2022-08-04

Topics:

Authors:

Sha, Chin-Kang

Lee, Shin-Jen

Tseng, Wei-Hong

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(97)00454-1

Cycloadduct 3 of the asymmetric Diels-Alder reaction of 2-siloxyfuran 2 and dimethyl acetylenedicarboxylate was converted into the enantiomerically pure desmethyl C,D-ring derivative 13 of Paclitaxel.

Full text of DOI:10.1016/S0040-4039(97)00454-1

Products guided by the article

Product name:(1S,4S)-1-[(S)-2,2-Bis-(4-methoxy-phenyl)-[1,3]dioxolan-4-yl]-4-(tert-butyl-dimethyl-silanyloxy)-7-oxa-bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid dimethyl ester

Cas No:189130-15-2

R&D Labs maybe for 189130-15-2

Reliable Pharma Technology (Shanghai) Co., Ltd.

Contact:0086-21-67676847-8008

Address:Lane 1500, No.68, Xinfei Road, Songjiang District, Shanghai, 201611, P.R.China.
Hefei Highzone Fine Chemical S&T CO.,LTD

Contact:86-0551-63663560

Address:room 1801 NO. 24 Shuguang RD.
Changzhou Litong Chemical Co., Ltd.

website:http://www.litonchem.com/

Contact:+86-519-86301238

Address:Laoba Rd, Hutang town Changzhou Jiangsu
NOVASYNCS CO., LTD

Contact:0512-63006287

Address:no.88.YISHENG Road,etdz-WUJIANG,SUZHOU,CHINA
NINGBO PANGS CHEM INT’L CO.,LTD.

Contact:+86-574-27666845

Address:FLOOR 21,BUILDING NO.11,XIN TIAN DI,NO.689 SHI JI ROAD,NINGBO CHINA

Relevant to this article

Ten isomeric five-ring bent-core mesogens: The influence of the direction of the carboxyl connecting groups on the mesophase behaviour

Doi:10.1039/b508488a
(2005)
Synthesis of 4-(Acylacetyl)-1-phenyl-2-pyrazolin-5-ones from 3-Acyl-2H-pyran-2,4(3H)-diones. Their Synthetic Applications to Functionalized 4-Oxopyrano<2,3-c>pyrazole Derivatives.

Doi:10.1021/jo00170a041
(1983)
Surface-mediated solid phase reactions: A simple and new method for the synthesis of α-aminophosphonates under solvent-free conditions

Doi:10.1246/cl.2001.880
(2001)
Design of the First-in-Class, Highly Potent Irreversible Inhibitor Targeting the Menin-MLL Protein–Protein Interaction

Doi:10.1002/anie.201711828
(2018)
Copper-Catalyzed Hydroarylation of Internal Alkynes: Highly Regio- and Diastereoselective Synthesis of 1,1-Diaryl, Trisubstituted Olefins

Doi:10.1021/acscatal.7b01847
(2017)
Doi:10.1039/CT9140501152
(1914)

Article Doi