Synthesis of enantiomerically pure desmethyl C,D-Ring derivative of paclitaxel (Taxo(TM)) via asymmetric Diels-Alder reaction of 2-siloxyfuran

DOI: 10.1016/S0040-4039(97)00454-1

Source and publish data:

Tetrahedron Letters p. 2725 - 2728 (1997)

Update date:2022-08-04

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Authors:

Sha, Chin-Kang

Lee, Shin-Jen

Tseng, Wei-Hong

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Article abstract of DOI:10.1016/S0040-4039(97)00454-1

Cycloadduct 3 of the asymmetric Diels-Alder reaction of 2-siloxyfuran 2 and dimethyl acetylenedicarboxylate was converted into the enantiomerically pure desmethyl C,D-ring derivative 13 of Paclitaxel.

Full text of DOI:10.1016/S0040-4039(97)00454-1

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