Regioselective opening of epoxides to β-amido alcohols under solid-liquid PTC conditions

Article abstract of DOI:10.1016/S0040-4020(97)00162-2

A study on the ring opening of a number of epoxides 1 with trifluoroacetamide (2) under solid-liquid phase transfer catalysis (SL-PTC) conditions has been performed. The reaction is completely regioselective affording β-amido alcohols 3 deriving from the attack of the nucleophile to the less substituted carbon atom of the oxirane ring.