Synthesis of 5'-C-branched thymidines and conversion to phosphoramidites

Article abstract of DOI:10.1080/07328319808004219

Thymidine was converted to its 5'-epoxy derivative, which was reacted with nucleophiles to give 5'-C-aminomethyl-, 5'-C-bromomethyl-, 5'-C- cyanomethyl, and 5'-C-methoxymethylthymidine derivatives with defined stereochemistry. 5'-C-ally-, 5'-C-hydroxymethyl-, 5'-C-hydroxypropyl-, and 5'-C-(imidazole-4-acetamido)methylthymidine derivatives were also prepared. The 5'-C-branched thymidines were converted to the corresponding phosphoramidites.

Full text of DOI:10.1080/07328319808004219

Nucleosides and Nucleotides
ISSN: 0732-8311 (Print) (Online) Journal homepage: http://www.tandfonline.com/loi/lncn19
Synthesis of 5′-C-Branched Thymidines and
Conversion to Phosphoramidites
Guangyi Wang & Patrick J. Middleton
To cite this article: Guangyi Wang & Patrick J. Middleton (1998) Synthesis of 5′-C-Branched
Thymidines and Conversion to Phosphoramidites, Nucleosides and Nucleotides, 17:6,
1033-1051, DOI: 10.1080/07328319808004219
To link to this article: http://dx.doi.org/10.1080/07328319808004219
Published online: 21 Aug 2006.
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Date: 21 May 2016, At: 15:41