Enzymes in organic chemistry - 5: First and chemo-enzymatic synthesis of α-aminooxyphosphonic acids of high enantiomeric excess

Article abstract of DOI:10.1016/S0040-4020(97)00174-9

α-Acyloxyphosphonates (±)-5a and (±)-5b, derived from 3-phenylpropionaldehyde and acetaldehyde, were resolved by lipase-catalyzed enantioselective hydrolysis. Three of the four chiral, non-racemic α-hydroxyphosphonates obtained had 99% ee, the fourth 91%.