Heterocycles p. 703 - 716 (1998)
Update date:2022-08-03
Topics:
Xia, Peng
Yang, Zheng-Yu
Xia, Yi
Zhang, Hao-Bing
Zhang, Ke-Hua
Sun, Xun
Chen, Ying
Zheng, Yun-Qing
An N-aryl-3-oxo-4-aza-5α -androst-1-ene-17β carboxamide and three N-aryl or alkyl substituted 17α -hydroxy-3-oxo-4-aza-5α -androstane-17β -carboxamides were synthesized as antiandrogen candidates from 3-oxoandrost-4-ene-17β - carboxylic acid and androst-4-ene-3,17-dione respectively. The chemo- and stereoselective reduction of 3-oxo-4-aza-5-ene intermediates with formic acid and their tautomerism in a solution of chloroform and methanol were described.
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