New non peptidic C5a receptor antagonists

DOI: 10.1016/S0960-894X(97)00124-8

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 907 - 912 (1997)

Update date:2022-08-04

Topics:

Authors:

Astles, Peter C.

Brown, Thomas J.

Cox, Paul

Halley, Frank

Lockey, Peter M.

McCarthy, Clive

McLay, Iain M.

Majid, Tahir N.

Morley, Andrew D.

Porter, Barry

Ratcliffe, Andrew J.

Walsh, Roger J.A.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(97)00124-8

A series of phenylguanidines which bind to the C5a receptor has been developed. The lead compound 1 (IC₅₀ = 30 μM), discovered through random screening, has been modified to provide 32 (RPR121154) with submicromolar activity. This compound was

Full text of DOI:10.1016/S0960-894X(97)00124-8

Products guided by the article

Product name:Benzenamine, 4-phenoxy-3-(phenylmethoxy)-

Cas No:190018-42-9

R&D Labs maybe for 190018-42-9

Changzhou Foreign Trade Corp

Contact:+86-519-86623222

Address:29F/D, 99 Yanling West Road, Changzhou, Jiangsu, China
Nanjing distinctions Medical Technology Co., Ltd.(expird)

Contact:+86-15996203785 13914714059

Address:nanjing,jiangsu , China
Dongtai Xinyuan Chemical Co., Ltd.

Contact:+86-21-56733000

Address:404F, 99Nong No.117 Zhongtan Rd. Shanghai
Jiangsu Cale New Material Co.ltd

Contact:+86-515-88334667/88203550

Address:Zhongshan 3rd Road, Coastal Chemical Industry Park, Yancheng, Jiangsu, China
Jinan Yijialian Economic and Trade Development Co., Ltd.

Contact:+86 0531-66729596

Address:jinan

Relevant to this article

An efficient synthesis of symmetrical bisamides catalysed by molecular iodine under neutral conditions

Doi:10.3184/174751912X13383107316656
(2012)
Efficient construction of novel D-ring modified steroidal dienamides and their cytotoxic activities

Doi:10.1016/j.ejmech.2013.05.035
(2013)
An experimental and theoretical approach to the photophysical properties of some Rh and Ir complexes incorporating the dipyrromethene ligand

Doi:10.1002/ejic.201201427
(2013)
N-Methyl-B-mesityldibenzo-1,4-azaborinine: the First Experimental Structure of a 1,4-Azaborinine Derivative

Doi:10.1039/c39920001247
(1992)
Approach to the core structure of the polycyclic alkaloid palhinine A

Doi:10.1055/s-0032-1316899
(2013)
Catalytic Pauson-Khand reaction in super critical fluids

Doi:10.1021/ja972099o
(1997)

Article Doi