New non peptidic C5a receptor antagonists

DOI: 10.1016/S0960-894X(97)00124-8

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 907 - 912 (1997)

Update date:2022-08-04

Topics:

Authors:

Astles, Peter C.

Brown, Thomas J.

Cox, Paul

Halley, Frank

Lockey, Peter M.

McCarthy, Clive

McLay, Iain M.

Majid, Tahir N.

Morley, Andrew D.

Porter, Barry

Ratcliffe, Andrew J.

Walsh, Roger J.A.

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Article abstract of DOI:10.1016/S0960-894X(97)00124-8

A series of phenylguanidines which bind to the C5a receptor has been developed. The lead compound 1 (IC₅₀ = 30 μM), discovered through random screening, has been modified to provide 32 (RPR121154) with submicromolar activity. This compound was

Full text of DOI:10.1016/S0960-894X(97)00124-8

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