Bioorganic and Medicinal Chemistry Letters p. 907 - 912 (1997)
Update date:2022-08-04
Topics:
Astles, Peter C.
Brown, Thomas J.
Cox, Paul
Halley, Frank
Lockey, Peter M.
McCarthy, Clive
McLay, Iain M.
Majid, Tahir N.
Morley, Andrew D.
Porter, Barry
Ratcliffe, Andrew J.
Walsh, Roger J.A.
A series of phenylguanidines which bind to the C5a receptor has been developed. The lead compound 1 (IC50 = 30 μM), discovered through random screening, has been modified to provide 32 (RPR121154) with submicromolar activity. This compound was
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(1997)
