A facile synthesis of 4-(trialkylmethyl)anilines by the reaction of 4- (trifluoromethyl)aniline with Grignard reagents

Article abstract of DOI:10.1080/00397919708006800

The treatment of 4-(trifluoromethyl)aniline (7) with primary Grignard reagents in ether yields the title products 14 (50-75%). A mechanistic pathway involves a series of fluoride elimination reactions followed by addition of the Grignard reagent to the resultant nonaromatic intermediate after each elimination step.

Full text of DOI:10.1080/00397919708006800

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Synthetic Communications: An
International Journal for Rapid
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Organic Chemistry
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A Facile Synthesis of 4-
(Trialkylmethyl)anilines
by the Reaction of 4-
(Trifluoromethyl)aniline with
Grignard Reagents
Shou-Yuan Lin a , Maryam Hojjat a & Lucjan
Strekowski a
a Department of Chemistry , Georgia State
University , Atlanta, Georgia, 30303, USA
Published online: 22 Aug 2006.
To cite this article: Shou-Yuan Lin , Maryam Hojjat & Lucjan Strekowski
(1997) A Facile Synthesis of 4-(Trialkylmethyl)anilines by the Reaction of 4-
(Trifluoromethyl)aniline with Grignard Reagents, Synthetic Communications: An
International Journal for Rapid Communication of Synthetic Organic Chemistry, 27:11,
1975-1980, DOI: 10.1080/00397919708006800
To link to this article: http://dx.doi.org/10.1080/00397919708006800
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