Bioorganic and Medicinal Chemistry Letters p. 939 - 944 (1997)
Update date:2022-08-04
Topics:
Raju
Okun, Ilya
Stavros, Fiona
Chan, Ming Fai
The potential proteolytic instability of the amide bond present in some ET(A) selective thiophenesulfonamide endothelin antagonists exemplified by TBC-10708 led us to investigate the replacement of this moiety with stable amide bond surrogates such as a trans double bond and an ethylene spacer. The effect of these replacements on the binding affinity is described.
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Doi:10.1021/jo970277q
(1997)Doi:10.1016/S0957-4166(97)00105-5
(1997)Doi:10.1021/acs.orglett.9b02203
(2019)Doi:10.3109/14756366.2012.724682
(2013)Doi:10.1021/om970933c
(1998)Doi:10.1002/hlca.19510340327
(1951)
