Bioorganic and Medicinal Chemistry Letters p. 939 - 944 (1997)
Update date:2022-08-04
Topics:
Raju
Okun, Ilya
Stavros, Fiona
Chan, Ming Fai
The potential proteolytic instability of the amide bond present in some ET(A) selective thiophenesulfonamide endothelin antagonists exemplified by TBC-10708 led us to investigate the replacement of this moiety with stable amide bond surrogates such as a trans double bond and an ethylene spacer. The effect of these replacements on the binding affinity is described.
View MoreBeijing Stable Chemcial Co.ltd
Contact:86-10-63785052
Address:A1301 Technological Edifice. No.4 FuFeng Road,FengTai District, Beijing. China
Contact:+86-0512-69209969
Address:Room 317,Lushan Road,Suzhou New District,Jiangsu Province,China.
Contact:+86-574-87065746
Address:10th Floor, No.787 Baizhang East Road,
ShangHai Soyoung Biotechnology Inc
website:http://www.soyoungbio.com
Contact:+86-21-69893009
Address:shanghai
Beyond Pharmaceutical Co., Ltd
Contact:+86-571-8195-3185
Address:No. 13-1, Liansheng Road, Yuhang District
Doi:10.1021/jo970277q
(1997)Doi:10.1016/S0957-4166(97)00105-5
(1997)Doi:10.1021/acs.orglett.9b02203
(2019)Doi:10.3109/14756366.2012.724682
(2013)Doi:10.1021/om970933c
(1998)Doi:10.1002/hlca.19510340327
(1951)
