Bioorganic and Medicinal Chemistry Letters p. 939 - 944 (1997)
Update date:2022-08-04
Topics:
Raju
Okun, Ilya
Stavros, Fiona
Chan, Ming Fai
The potential proteolytic instability of the amide bond present in some ET(A) selective thiophenesulfonamide endothelin antagonists exemplified by TBC-10708 led us to investigate the replacement of this moiety with stable amide bond surrogates such as a trans double bond and an ethylene spacer. The effect of these replacements on the binding affinity is described.
View MoreHAINAN JINYING IMPORT AND EXPORT CO. LTD
Contact:+86-898-32875423
Address:A SECTION 19TH FL, TIMES SQUARE, NO.2 GUO MAO AVENUE HAIKOU, HAINAN, P. R. OF CHINA
Chemieliva Pharmaceutical Co., Ltd.
website:http://www.chemieliva.com
Contact:+86-23-67770219
Address:99 Longhua Road, Yubei District, 401147, Chongqing, China Email: sales@chemieliva.com Tel:0086-23-67770219 Fax: 0086-23-67770220 Attn: Andy Huang
Puyang Huicheng Electronic Material Co., Ltd
website:http://huichengchem.weba.testwebsite.cn/index_en.html
Contact:+86-393-8910800
Address:West Section Shengli Road, Puyang457000, China
Guangzhou Chemical Reagent Factory
Contact:+86-20-8435 9820 or 8435 7345
Address:Southern Guangzhou, Guangdong, China
Jiangsu Chiatai Qingjiang Pharmaceutical Co.,Ltd
Contact:+86-517-86283327
Address:9 North Hantai Road, Huaian, China
Doi:10.1021/jo970277q
(1997)Doi:10.1016/S0957-4166(97)00105-5
(1997)Doi:10.1021/acs.orglett.9b02203
(2019)Doi:10.3109/14756366.2012.724682
(2013)Doi:10.1021/om970933c
(1998)Doi:10.1002/hlca.19510340327
(1951)
