
Tetrahedron Letters p. 3539 - 3542 (1997)
Update date:2022-08-03
Topics:
Umemura, Kazuyuki
Noda, Hirofumi
Yoshimura, Juji
Konn, Akihito
Yonezawa, Yasuchika
Shin, Chung-Gi
Fragment A derivative(13) of nosiheptide, useful for the total synthesis, was obtained by stepwise introduction of the 25-bis{(4ethoxycarbonyl)-2-thiazolyl} groups and 6-{(2-substituted)-4-thiazolyl} group into 3-hydroxy-5-cyanopyridine (3). The total yield was 7.6% via 14 steps.
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(1997)