Chemical and Pharmaceutical Bulletin p. 966 - 970 (1997)
Update date:2022-08-03
Topics:
Nagatsu, Akito
Tabunoki, Yuichiro
Nagai, Shin-Ichi
Ueda, Taisei
Sakakibara, Jinsaku
Hidaka, Hiroyoshi
7-Carboxymethylmonensin (3), 7-aminomonensin (4), and 7-oxomonensin (5) were synthesized via protected 7-oxomonensin (2), which is expected to be a useful intermediate for the preparation of various monensin derivatives. Compounds 3-5 exhibited smaller ion transport activity than monensin (1).
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