3,7-Functionalized-10-methyl phenothiazine: A potential turn scaffold in peptidomimetics

Article abstract of DOI:10.1016/S0960-894X(97)00164-9

Molecular modeling studies suggest that the phenothiazine nucleus, embedded in a peptide via attachments at the 3- and 7-positions, may be a possible surrogate for the α-carbon backbone of five residue turns in a variety of proteins. The synthesis of the orthogonally-protected Fmoc 3-aminoethyl-7-carboxyethyl-10-methylphenothiazine (1) is described.