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Studies on β-lactam antibiotics, synthesis and antibacterial activity of novel 1β-methylcarbapenems related to FR21818: 5-membered ring analogs

DOI: 10.1016/S0960-894X(97)00230-8

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1409 - 1414 (1997)

Update date:2022-08-04

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Authors:

Azami, HidenoriAzami, Hidenori

Barrett, DavidBarrett, David

Tanaka, AkiraTanaka, Akira

Sasaki, HiroshiSasaki, Hiroshi

Matsuda, KeijiMatsuda, Keiji

Sakurai, MinoraSakurai, Minora

Matsumoto, YoshimiMatsumoto, Yoshimi

Tawara, ShuichiTawara, Shuichi

Chiba, ToshiyukiChiba, Toshiyuki

Sakane, KazuoSakane, Kazuo

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Article abstract of DOI:10.1016/S0960-894X(97)00230-8

The synthesis and biological activity of the novel series of 1β-methylcarbapenems 1 are described. Most compounds displayed extremely potent antibacterial activity and high renal DHP-I stability. The best compound in this series, FR21818 (1a) displayed ex

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Full text of DOI:10.1016/S0960-894X(97)00230-8

Products guided by the article

Product name:[(2S,4R)-1-Benzyl-4-(tert-butyl-dimethyl-silanyloxy)-pyrrolidin-2-yl]-[2-(tert-butyl-dimethyl-silanyl)-3-methyl-3H-imidazol-4-yl]-methanol

Cas No:191734-32-4

191734-32-4

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