Asymmetric synthesis of (R)-nilvadipine and (S)-NB 818 via regioselective bromination of chiral 1,4-dihydropyridines as a key step and enzymatic resolution of racemic 2-hydroxymethyl-1,4-dihydropyridine derivatives

DOI: 10.1248/cpb.45.869

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 869 - 876 (1997)

Update date:2022-08-03

Topics: Asymmetric synthesis Racemic Enzymatic Resolution

Authors:

Ebiike, Hirosato

Maruyama, Kaori

Ozawa, Yumi

Yamazaki, Yukiyoshi

Achiwa, Kazuo

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Article abstract of DOI:10.1248/cpb.45.869

Optically active 2-hydroxymethyl-1,4,dihydropyridines were obtained by lipase-catalyzed hydrolysis or transesterification of racemic materials. Chiral NB 818 and nilvadipine have been synthesized from chiral 2- hydroxymethyl-1,4-dihydropyridine. On the ot

Full text of DOI:10.1248/cpb.45.869

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