Asymmetric synthesis of (R)-nilvadipine and (S)-NB 818 via regioselective bromination of chiral 1,4-dihydropyridines as a key step and enzymatic resolution of racemic 2-hydroxymethyl-1,4-dihydropyridine derivatives

DOI: 10.1248/cpb.45.869

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 869 - 876 (1997)

Update date:2022-08-03

Topics: Asymmetric synthesis Racemic Enzymatic Resolution

Authors:

Ebiike, Hirosato

Maruyama, Kaori

Ozawa, Yumi

Yamazaki, Yukiyoshi

Achiwa, Kazuo

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.45.869

Optically active 2-hydroxymethyl-1,4,dihydropyridines were obtained by lipase-catalyzed hydrolysis or transesterification of racemic materials. Chiral NB 818 and nilvadipine have been synthesized from chiral 2- hydroxymethyl-1,4-dihydropyridine. On the ot

Full text of DOI:10.1248/cpb.45.869

NII-Electronic Library Service

Products guided by the article

Product name:isopropyl 2-acetoxymethyl-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3-methoxycarbonyl-5-piperidinecarboxylate

Cas No:191742-12-8

R&D Labs maybe for 191742-12-8

Tianjin Anda North Industrial & Business Co.Ltd.

Contact:86-22-24999306

Address:No.11 Erwei Road,Dongli Development Area,Tianjin,China
Jinan Decheng Hemu Medical Technology Co.，Ltd.

Contact:+86-531-68650525

Address:NO.554 Zhengfeng Road High-new Technology Development Zone
HuiFeiChem PharmaTech Co.Ltd

Contact:0510-85393305

Address:1619 Huishan Avenue, Huishan District, Wuxi,
Shenzhen ZheYi Chemicals Co.,LTD(Shanghai Branch)

Contact:+86-21-54159691

Address:Room1002,Building No.2, Lane 98 Bixiu Road,Minhang District, Shanghai,China 201100
Evershine Chemical CO Ltd

Contact:+86-571-87010026

Address:202, Zhenhua Road,

Relevant to this article

Total synthesis of (+)-polyoxin J

Doi:10.1039/c39950002127
(1995)
Doi:10.1016/S0031-9422(00)94444-3
(1976)
A new protocol for the acetoxyallylation of aldehydes mediated by indium in THF

Doi:10.1021/ol016315g
(2001)
Trimethylsilylcarbene and Bis(trimethylsilyl) Formaldehyde Azine Complexes of Chiral Bis(4-isopropyloxazolinyl)pyridine(dichloro)ruthenium(II)

Doi:10.1039/c39940001315
(1994)
Multiple bonds between transition metals and main-group elements, 163 Nitrogen-donor adducts of organorhenium( VII) oxides: Structural and catalytic aspects

Doi:10.1016/S0022-328X(96)06919-7
(1997)
Biological activity of neutral and cationic iridium(III) complexes with κp and κp,κS coordinated Ph₂PCH₂S(O) _xPh (x = 0-2) ligands

Doi:10.1016/j.ejmech.2013.08.025
(2013)

Article Doi