Bioorganic and Medicinal Chemistry Letters p. 1387 - 1392 (1997)
Update date:2022-08-05
Topics:
Tse, H. L. Allan
Knight, David J.
Coates, Jonathan A. V.
Mansour, Tarek S.
The synthesis of constrained analogues of 2'-nor-cyclic nucleosides monophosphates containing a thiomethylene tether was readily accomplished from the oxathiolane intermediate 4. The uracil, cytosine, and 5-bromocytosine spirophosphate analogues 22, 16, and 25 were inhibitory to HCMV replication in Flow 2002 cells.
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(1997)
