Total synthesis of (+)-4-deoxygigantecin

Article abstract of DOI:10.1016/S0040-4039(97)00856-3

(+)-4-Deoxygigantecin (1) was totally synthesized from enantiomerically pure (-)-muricatacin (3). Thus, 3 afforded the key intermediate 5 through a five-step reaction sequence, which was then converted to (+)-4-deoxygigantecin (1) via the formation of bis-tetnhydrofuran unit 11 and a coupling reaction with iodo lactone synthon 16.