Bioorganic and Medicinal Chemistry Letters p. 73 - 77 (2007)
Update date:2022-08-04
Topics:
Freskos, John N.
Fobian, Yvette M.
Benson, Timothy E.
Bienkowski, Michael J.
Brown, David L.
Emmons, Thomas L.
Heintz, Robert
Laborde, Alice
McDonald, Joseph J.
Mischke, Brent V.
Molyneaux, John M.
Moon, Joseph B.
Mullins, Patrick B.
Bryan Prince
Paddock, Donna J.
Tomasselli, Alfredo G.
Winterrowd, Gregory
We describe a novel series of potent inhibitors of human β-secretase. These compounds possess the hydroxyethyl amine transition state isostere. A 2.5 A crystal structure of inhibitor 32 bound to BACE is provided.
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