Journal of Organic Chemistry p. 4615 - 4625 (1985)
Update date:2022-08-02
Topics:
Evans, Ben E.
Rittle, Kenneth E.
Homnick, Carl F.
Springer, James P.
Hirshfield, Jordan
Veber, Daniel F.
A stereocontrolled synthesis of the hydroxyethylene dipeptide isosteric unit 1 is described.This synthesis is capable of providing all eight stereoisomers of 1 and is amenable to variation of substituents R1 and R2.Also described are the novel chiral epoxides 2 and substituted γ-lactones 3, key intermediates in this synthesis having potentially broad application.
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(1981)
