Spectral studies and in vitro antimicrobial activity of new organotin(IV) complexes of Schiff bases derived from amino acids

Article abstract of DOI:10.1246/bcsj.70.1331

Some new di- and triphenyltin(IV) complexes of the general formulae Ph₂SnL and Ph₃SnL', where H₂L/HL' = Schiff bases derived from the condensation of 2-hydroxy-1-naphthaldehyde (H₂L) and benzaldehyde (HL') with glycine (H₂L-1/HL'-1), DL-α-alanine (H₂L-2/HL'-2), L-methionine (H₂L-3/HL'-3), DL-valine (H₂L-4/HL-4), D-phenylalanine (H₂L-5/HL'-5), 2-aminobutyric acid (H₂L-6/HL'-6), and L-leucine (H₂L-7/HL'-7), have been synthesized and characterized by elemental analyses, molar conductance, electronic, infrared and far-infrared, multinuclear magnetic resonance (¹H, ¹³C, and ¹¹⁷Sn), and ¹¹⁹Sn Mossbauer studies. Thermal decomposition of a few complexes using TG, DTG, and DTA techniques indicates the formation of SnO₂ as a residue. The complexes have also been tested in vitro against bacteria [Streptococcus faecalis, Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus Penicillin resistance (2500 units)] and fungi [Candida albicans, Cryptococcus neoformans, Sporotrichum schenckii, Trichophyton mentagrophytes, and Aspergillus fumigatus]. All of the complexes show remarkable activity.