Bioorganic and Medicinal Chemistry Letters p. 5226 - 5230 (2006)
Update date:2022-08-03
Topics:
Kazmierski, Wieslaw M.
Furfine, Eric
Spaltenstein, Andrew
Wright, Lois L.
We have developed efficient synthesis of morpholinone-based cyclic mimetics of the P1/P2 portion of the HIV-1 protease inhibitor Amprenavir. This effort led to discovery of allyl- and spiro-cyclopropyl-P2-substituted inhibitors 17 and 31, both 500 times m
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