European Journal of Medicinal Chemistry p. 425 - 431 (1997)
Update date:2022-08-03
Topics:
Kaltenbronn
Quin III
Reisdorph
Klutchko
Reynolds
Welch
Flynn
Doherty
The synthesis and SAR relationships of a series of 4-benzyloxy-3-methylbenzofuran-2-carboxylic acids are described. Compounds from this series show 2- to 16-fold selective binding to the ET(A) receptor in the micromolar range, and two compounds from this series (32 and 40) were demonstrated to exhibit ET(A) antagonist activity.
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