Benzofuran derivatives as ET(A)-selective, non-peptide endothelin antagonists

DOI: 10.1016/S0223-5234(97)81679-0

Source and publish data:

European Journal of Medicinal Chemistry p. 425 - 431 (1997)

Update date:2022-08-03

Topics:

Authors:

Kaltenbronn

Quin III

Reisdorph

Klutchko

Reynolds

Welch Welch

Flynn Flynn

Doherty Doherty

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Article abstract of DOI:10.1016/S0223-5234(97)81679-0

The synthesis and SAR relationships of a series of 4-benzyloxy-3-methylbenzofuran-2-carboxylic acids are described. Compounds from this series show 2- to 16-fold selective binding to the ET(A) receptor in the micromolar range, and two compounds from this series (32 and 40) were demonstrated to exhibit ET(A) antagonist activity.

Full text of DOI:10.1016/S0223-5234(97)81679-0

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