Bioorganic and Medicinal Chemistry Letters p. 1683 - 1688 (1997)
Update date:2022-08-03
Topics:
Fukuda, Yasumichi
Furuta, Hirosuke
Shiga, Futoshi
Oomori, Yasuo
Kusama, Yoshie
Ebisu, Hiroyuki
Terashima, Shiro
The title synthesis was achieved by employing oxidative cyclization of the enaminoester as a key step. Some of these novel 3 methoxycarbonyl-2- trifluoromethylcyclopropapyrroloindole (MCTFCPI) derivatives, dl-10c,d, (+)- 10d, and (S)-21b were found to exhibit antitumor activity against murine leukemia and murine solid tumors more prominent than that of the known CPI derivatives dl-4 and the clinical trial candidates 5 and 7.
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Doi:10.1002/(SICI)1099-1344(199803)41:3<211::AID-JLCR69>3.0.CO;2-9
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