Tetrahedron Letters p. 5185 - 5188 (1997)
Update date:2022-08-03
Topics:
Akaji, Kenichi
Kiso, Yoshiaki
A novel intramolecular macrocyclization reaction on solid support; using Heck reaction was achieved. The Heck coupling of acrylic acid amide to 3-iodobenzylamine on solid support proceeds smoothly to yield a cyclic tetrapeptide derivative containing a new 3-substituted cinnamic acid template and Arg-Gly-Asp sequence. The macrocyclization reaction takes place more rapidly on solid support than in solution.
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Doi:10.1021/acs.joc.1c00025
(2021)Doi:10.1016/S0960-894X(97)00305-3
(1997)Doi:10.1055/s-1997-5754
(1997)Doi:10.1039/c8dt01668b
(2018)Doi:10.1021/jo970484q
(1997)Doi:10.1016/S0960-894X(99)00179-1
(1999)
