Bioorganic and Medicinal Chemistry Letters p. 1811 - 1816 (1997)
Update date:2022-08-03
Topics:
Lin, Yang-I.
Bitha, Panayota
Li, Zhong
Sakya, Subas M.
Strohmeyer, Timothy W.
Lang Jr., Stanley A.
Yang, Youjun
Bhachech, Niraja
Weiss, William J.
Petersen, Peter J.
Jacobus, Nilda V.
Bush, Karen
Testa, Raymond T.
Mono and bis double ester prodrugs of aminomethyl THF 1β-methylcarbapenems 1 were Mono double ester derivatives (2, 4 and 7) did not demonstrate significantly improved oral activity due to the presence of the charged species. However, bis double ester derivatives (3 and 5) demonstrated enhanced oral activity.
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(1997)
