Bioorganic and Medicinal Chemistry Letters p. 1937 - 1940 (1996)
Update date:2022-08-05
Topics:
Coburn, Craig A.
Young, Mary Beth
Hungate, Randall W.
Isaacs, Richard C.A.
Vacca, Joseph P.
Huff, Joel R.
A series of analogs of CRIXIVAN containing various aromatic P1 ligands were prepared and evaluated for inhibition of the HIV-1 protease enzyme. These new compounds were found to be effective inhibitors at nanomolar concentrations in the in vitro enzyme inhibition assay as well as the whole cell assay.
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