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Aromatic P1 replacements for the highly potent HIV-1 protease inhibitor CRIXIVAN

DOI: 10.1016/0960-894X(96)00345-9

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1937 - 1940 (1996)

Update date:2022-08-05

Topics:

Authors:

Coburn, Craig A.Coburn, Craig A.

Young, Mary BethYoung, Mary Beth

Hungate, Randall W.Hungate, Randall W.

Isaacs, Richard C.A.Isaacs, Richard C.A.

Vacca, Joseph P.Vacca, Joseph P.

Huff, Joel R.Huff, Joel R.

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Article abstract of DOI:10.1016/0960-894X(96)00345-9

A series of analogs of CRIXIVAN containing various aromatic P1 ligands were prepared and evaluated for inhibition of the HIV-1 protease enzyme. These new compounds were found to be effective inhibitors at nanomolar concentrations in the in vitro enzyme inhibition assay as well as the whole cell assay.

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Full text of DOI:10.1016/0960-894X(96)00345-9

Products guided by the article

Product name:(2R,4S)-2-Benzyl-1-((3aS,8aR)-2,2-dimethyl-8,8a-dihydro-3aH-indeno[1,2-d]oxazol-3-yl)-4-hydroxy-5-(2-methylsulfanyl-phenyl)-pentan-1-one

Cas No:194204-25-6

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