
Tetrahedron Letters p. 6173 - 6176 (1997)
Update date:2022-08-04
Topics:
Vroman, Jeffrey A.
Khan, Ikhlas A.
Avery, Mitchell A.
A new route to novel 9-substituted-10-deoxoartemisinin analogs (13, 14) was developed employing photoxygenation of homologated derivatives of artemisinic acid (9, 10). Conjugate addition to the acrylate moiety of artemisinic acid 2 was made possible by in situ protection as a silyl ester, Cu(I)-catalyzed 1,4-addition of RMgX, and deprotection.
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