New spermine and spermidine derivatives as potent inhibitors of trypanosoma cruzi trypanothione reductase

DOI: 10.1016/S0968-0896(97)00070-9

Source and publish data:

Bioorganic and Medicinal Chemistry p. 1249 - 1256 (1997)

Update date:2022-07-29

Topics:

Authors:

Bonnet, Beatrice

Soullez, David

Davioud-Charvet, Elisabeth

Landry, Valerie

Horvath, Dragos

Sergheraert, Christian

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0968-0896(97)00070-9

Several spermine and spermidine derivatives containing 2-amino diphenylsulfide substituents were prepared and tested for their inhibiting effects on Trypanosoma cruzi trypanothione reductase. IC₅₀ values were assessed between 0.3 and 3 μM. Compound 32 (K(i) = 0.4 μM) is the most potent TR inhibitor described so far.

Full text of DOI:10.1016/S0968-0896(97)00070-9

Products guided by the article

Product name:Propanamide, 3-bromo-N-[5-methoxy-2-(phenylthio)phenyl]-

Cas No:195073-73-5

R&D Labs maybe for 195073-73-5

Yingkou Sanzheng Organic Chemical Co. Ltd.

Contact:+86-417-3638818

Address:25 Gengxinli Village, Daqing Road, Yingkou, Liaoning, China
Guangxi Bonger Pharmaceutical Co., Ltd

website:http://napo.lookchem.com/

Contact:+86-18817331185

Address:Donghai Industrial Zone, Tiandong Country,Guangxi,China
suzhou chukai pharmateach co,.ltd

Contact:86-512-88812511

Address:Building 3, Wujiang Scientific Innovation Park, 2358 Changan Rd, Wujiang 215200, Jiangsu Province, P. R. China
Wuhan Konberd Biotech Co., Ltd.

Contact:+86-27-87205925

Address:NO.666, Gaoxin Road, Eastlake High-tech zone
Hangzhou Dingyan Chem Co., Ltd

website:http://www.dingyanchem.com

Contact:86-571-87157530-8007

Address:RM.1118,NO.1 Building, Baiyun Tower,Jianggan Area, Hangzhou city, China,310004

Relevant to this article

Synthesis and evaluation of benzophenone-based photoaffinity labeling analogs of prenyl pyrophosphates containing stable amide linkages

Doi:10.1016/S0960-894X(97)00373-9
(1997)
Doi:10.1039/j39680001882
(1968)
The application of microwave dielectric heating to the synthesis of arene-metal complexes. Synthesis of [(η-arene) (CO)₃Mn]PF₆ complexes and [(η-arene) (η-cyclopentadienyl)Fe][PF₆] complexes with triphenylphosphine, tert-butylbenzenes and a sterically hindered phenol as arene ligands

Doi:10.1016/S0022-328X(97)00289-1
(1997)
Synthesis of covalent probes for the radiolabeling of the cannabinoid receptor

Doi:10.1021/jo0264978
(2003)
Facile route t ferrocifen, 1-<4-(2-dimethylaminoethoxy)>-1-(phenyl-2-ferrocenyl-but-1-ene), first organometallic analogue of tamoxifen, by the McMurry reaction

Doi:10.1016/S0022-328X(97)00086-7
(1997)
Nickel catalyzed addition of organozincates to optically pure vinylic sulfoxides, synthesis of the phosphodiesterase IV inhibitor L-765,527 (CDP-840).

Doi:10.1016/S0040-4039(97)01766-8
(1997)

Article Doi