Bioorganic and Medicinal Chemistry p. 1249 - 1256 (1997)
Update date:2022-07-29
Topics:
Bonnet, Beatrice
Soullez, David
Davioud-Charvet, Elisabeth
Landry, Valerie
Horvath, Dragos
Sergheraert, Christian
Several spermine and spermidine derivatives containing 2-amino diphenylsulfide substituents were prepared and tested for their inhibiting effects on Trypanosoma cruzi trypanothione reductase. IC50 values were assessed between 0.3 and 3 μM. Compound 32 (K(i) = 0.4 μM) is the most potent TR inhibitor described so far.
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Doi:10.1016/S0960-894X(97)00373-9
(1997)Doi:10.1039/j39680001882
(1968)Doi:10.1016/S0022-328X(97)00289-1
(1997)Doi:10.1021/jo0264978
(2003)Doi:10.1016/S0022-328X(97)00086-7
(1997)Doi:10.1016/S0040-4039(97)01766-8
(1997)
