New spermine and spermidine derivatives as potent inhibitors of trypanosoma cruzi trypanothione reductase

DOI: 10.1016/S0968-0896(97)00070-9

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Bioorganic and Medicinal Chemistry p. 1249 - 1256 (1997)

Update date:2022-07-29

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Authors:

Bonnet, Beatrice

Soullez, David

Davioud-Charvet, Elisabeth

Landry, Valerie

Horvath, Dragos

Sergheraert, Christian

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Article abstract of DOI:10.1016/S0968-0896(97)00070-9

Several spermine and spermidine derivatives containing 2-amino diphenylsulfide substituents were prepared and tested for their inhibiting effects on Trypanosoma cruzi trypanothione reductase. IC₅₀ values were assessed between 0.3 and 3 μM. Compound 32 (K(i) = 0.4 μM) is the most potent TR inhibitor described so far.

Full text of DOI:10.1016/S0968-0896(97)00070-9

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