Nickel catalyzed addition of organozincates to optically pure vinylic sulfoxides, synthesis of the phosphodiesterase IV inhibitor L-765,527 (CDP-840).

DOI: 10.1016/S0040-4039(97)01766-8

Source and publish data:

Tetrahedron Letters p. 7131 - 7134 (1997)

Update date:2022-07-29

Topics:

Authors:

Houpis, Ioannis N.

Molina, Audrey

Dorziotis, Ilias

Reamer, Robert A.

Volante Volante

Reider, Paul J.

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Article abstract of DOI:10.1016/S0040-4039(97)01766-8

Ph₃lZnMgCl was added to the optically pure sulfoxide 3 in the presence of Ni(acac)₂ to give, after desulfurization, the phosphodiesterase N inhibitor 1 in good yield and 92% enantiomeric excess.

Full text of DOI:10.1016/S0040-4039(97)01766-8

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