Stereospecific coupling of α-aminoalkylcuprates with vinyl iodides

Article abstract of DOI:10.1016/S0040-4039(97)01326-9

Allylic amines can be prepared stereospecifically via a coupling reaction of vinyl iodides and α-aminoalkylcuprates prepared from the corresponding lithium reagents and LiCl solubilized CuCN. The reaction works well for both E and Z dialkyl substituted vinyl iodides. 1-Iodoalkynes can also be coupled in modest yields to afford propargyl amines.