Bioorganic and Medicinal Chemistry Letters p. 3603 - 3608 (1998)
Update date:2022-07-31
Topics:
Adang, Anton E.P.
Lucas, Hans
De Man, Adrianus P.A.
Engh, Richard A.
Grootenhuis, Peter D.J.
Replacement of the noragmatine group in thrombin inhibitors with a β- alanyl-guanidine group resulted in a nearly equipotent and more selective compound 8 despite the fact that the pK(a) of this P1 moiety is five orders of magnitude lower. Furt
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