Annulation of functionalized hexadienones as an efficient regioselective approach to N-aryl-2-(trifluoromethyl)-4-pyridinamines

Article abstract of DOI:10.1016/S0040-4039(99)00758-3

Readily accessible fluorinated N-arylenaminones 3 were reacted with N,N- dimethylformamide dimethylacetal to produce functionalized hexadienones 4. Ring closure of 4 with ammonium acetate afforded selectively N-aryl-2- (trifluoromethyl)-4-pyridinamines 5