Improved synthesis and additional pharmacology of the potent analgetic (-) 5 m hydroxyphenyl 2 methylmorphan

Article abstract of DOI:10.1021/jm00258a019

In the dimethylaminoethylation of 2 m methoxyphenylcyclohexanone an improved C:O alkyl ratio (3:4) was obtained. This combined with a better resolution procedure affords a practicable synthesis of the strong analgesic (-) 5 (m hydroxyphenyl) 2 methylmorph