Synthesis of Optically Active Condensed Tetrahydropyridin-3-ones as Precursors of Alkaloid Analogues

Article abstract of DOI:10.1055/s-1997-1521

Reaction of α-aminoester 2 with o-bromobenzylbromide or 3-bromo-2-bromomethylindole 1 gives N-alkylation products 3, which further undergo intramolecular acylation upon Br/Li-exchange. This sequence represents the first access to optically active condense