Asymmetric synthesis of both enantiomers of 2-(dimethylamino)-1-[3-methoxy-2-(1-methyletyhoxy)phenyl]ethanol

DOI: 10.1016/S0223-5234(97)82773-0

Source and publish data:

European Journal of Medicinal Chemistry p. 881 - 888 (1997)

Update date:2022-08-03

Topics:

Authors:

Philippo

Fett Fett

Bovy Bovy

Barras Barras

Angel Angel

Georges Georges

Ochsenbein

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0223-5234(97)82773-0

Both enantiomers of 2-(dimethylamino)-1-[3- methoxy-2-(1-methylethoxy)phenyl]ethanol were synthetized by a stereoselective route and evaluated in vitro for their uroselectivity in comparison with other α1-adrenoceptor agonists. The most potent enantiomer was structurally characterized by X-ray crystallographic analysis.

Full text of DOI:10.1016/S0223-5234(97)82773-0

Products guided by the article

Product name:2-isopropoxy-1-methoxy-3-vinylbenzene

Cas No:197566-30-6

R&D Labs maybe for 197566-30-6

SHENYANG COMEBOARD TECHNOLOGY CO., LTD

Contact:+86-24-25724626

Address:Room2210,Tianbao International Building,No.8-1 Weigong South Street,Tiexi District,Shenyang,China
Nanjing Habo Medical Technology Co., Ltd.

Contact:025－85769882

Address:No.108. Ganjiabian east. Qixia District .Nanjing
shanghai jinshan pharmaceutical Co.,Ltd

Contact:021-57363011，13681638167

Address:No. 7966 Tingfeng Road,Jinshan,Shanghai,China
Shanghai Harvest Chemical Ind. Co., Ltd.

Contact:021-51385350

Address:ROOM 806-807, AI LI CHEN BUILDING, No.333 JINGXIANG ROAD, PUDONG DISTRICT, 201206, SHANGHAI
Beijing Tianjia Chemical Science & Technology Co.,Ltd

Contact:86-0550-2392698

Address:No.388, Shiliang Road (East),

Relevant to this article

New Syntheses of 2,4-Diaminopyrroles and Aminopyrrolinones

Doi:10.1007/BF00807103
(1997)
Synthesis of macrocyclic polyhydroxy tetralactams derived from L-tartaric acid and β-hydroxyglutaric acid

Doi:10.1016/S0040-4020(97)00896-X
(1997)
Asymmetric synthesis of all four isomers of topographically constrained novel amino acids: β-isopropyltyrosines

Doi:10.1016/S0957-4166(97)00381-9
(1997)
Development of dual-acting agents for thromboxane receptor antagonism and thromboxane synthase inhibition. 2. Design, synthesis, and evaluation of a novel series of phenyl oxazole derivatives

Doi:10.1016/S0960-894X(98)00353-9
(1998)
Palladium(0)-Catalyzed Dearomative [3 + 2] Cycloaddition of 3-Nitroindoles with Vinylcyclopropanes: An Entry to Stereodefined 2,3-Fused Cyclopentannulated Indoline Derivatives

Doi:10.1021/acs.orglett.7b00784
(2017)
Potent antiinflammatory 3-thiazole-4(5)-acetic acids of 1,2-benzoisothiazole

Doi:10.1016/S0960-894X(97)00449-6
(1997)

Article Doi