Asymmetric synthesis of both enantiomers of 2-(dimethylamino)-1-[3-methoxy-2-(1-methyletyhoxy)phenyl]ethanol

DOI: 10.1016/S0223-5234(97)82773-0

Source and publish data:

European Journal of Medicinal Chemistry p. 881 - 888 (1997)

Update date:2022-08-03

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Authors:

Philippo

Fett Fett

Bovy Bovy

Barras Barras

Angel Angel

Georges Georges

Ochsenbein

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Article abstract of DOI:10.1016/S0223-5234(97)82773-0

Both enantiomers of 2-(dimethylamino)-1-[3- methoxy-2-(1-methylethoxy)phenyl]ethanol were synthetized by a stereoselective route and evaluated in vitro for their uroselectivity in comparison with other α1-adrenoceptor agonists. The most potent enantiomer was structurally characterized by X-ray crystallographic analysis.

Full text of DOI:10.1016/S0223-5234(97)82773-0

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