Synthesis of 4-carboethoxy-4-oxazolin-2-ones from 3-nosyloxy-2-ketoesters

DOI: 10.1016/S0040-4039(97)10854-1

Source and publish data:

Tetrahedron Letters p. 1283 - 1286 (1998)

Update date:2022-08-02

Topics:

Authors:

Hoffman, Robert V.

Johnson, M. Catherine

Okonya, John F.

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Article abstract of DOI:10.1016/S0040-4039(97)10854-1

3-Nosyloxy-2-ketoesters, available from 2-ketoesters, react efficiently with methyl carbamate and tosic acid in refluxing toluene to provide 4-carboalkoxy-4-oxazolin-2-ones in good yields (41-84%).

Full text of DOI:10.1016/S0040-4039(97)10854-1

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Product name:5-methyl-4-ethoxycarbonyl-4-oxazolin-2-one

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