Bioorganic and Medicinal Chemistry Letters p. 967 - 972 (1999)
Update date:2022-08-03
Topics:
Beck, James P.
Arvanitis, Argyrios G.
Curry, Matt A.
Rescinito, Joseph T.
Fitzgerald, Larry W.
Gilligan, Paul J.
Zaczek, Robert
Trainor, George L.
A series of purin-8-ones was prepared and discovered to have excellent binding affinity to the CRH-R1 receptor. Structure-activity studies focused on amine side-chain optimization, urea substitution and pyridyl isostere incorporation. Thus, the highly potent purin-8-ones show promise as a new class of potential anxiolytics and/or antidepressants.
View MoreZhengzhou Minzhong Pharmaceutical Co.,ltd
Contact:0086-371-65797115
Address:15/F,Jiangshan Bldg, NO.126 Huanghe Road,Zhengzhou, China
website:http://www.chemdow.com
Contact:0086-10-82435335
Address:Room 401,Unit 3,4th Floor,Shangdijiayuan,Shangdi East Road, Haidian District,Beijing
Chengdu Boon Stream Chemical Industry Co.,Ltd.
Contact:+86-28-83156758
Address:No.859,Dongzikou Road,Jinniu District,Chengdu,Sichuan,P.R.China
Lishui Nanming Chemical Co., Ltd(expird)
Contact:+86-0578-2134101，2697830
Address:No.19 Tongji Road Shuige Industrial zone
SJZ Chenghui Chemical Co., Ltd.
Contact:86-311-87713916
Address:no.368 youyi north avenue
Doi:10.1002/chem.19970030820
(1997)Doi:10.1021/jo971049z
(1997)Doi:10.1016/S0957-4166(97)00404-7
(1997)Doi:10.1039/d0nj03104f
(2020)Doi:10.1016/j.bioorg.2019.01.036
(2019)Doi:10.1016/S0022-328X(96)06833-7
(1997)
