Polyketide library synthesis: Iterative assembly of extended polypropionates using (R)- and (S)-1-(benzyloxy)-2-methylpentan-3-one

Article abstract of DOI:10.1016/S0040-4039(97)01751-6

The heptapropionates 5 and 20 were synthesised by iterative application of the boron-mediated aldol reaction of ethyl ketone (R)-4 and subsequent reduction. Polyketide library diversification was realised by varying the ketone configuration and substitution in the aldol bond constructions.