Polyketide library synthesis: Iterative assembly of extended polypropionates using (R)- and (S)-1-(benzyloxy)-2-methylpentan-3-one

DOI: 10.1016/S0040-4039(97)01751-6

Source and publish data:

Tetrahedron Letters p. 7441 - 7444 (1997)

Update date:2022-08-03

Topics:

Authors:

Paterson, Ian

Scott, Jeremy P.

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Article abstract of DOI:10.1016/S0040-4039(97)01751-6

The heptapropionates 5 and 20 were synthesised by iterative application of the boron-mediated aldol reaction of ethyl ketone (R)-4 and subsequent reduction. Polyketide library diversification was realised by varying the ketone configuration and substitution in the aldol bond constructions.

Full text of DOI:10.1016/S0040-4039(97)01751-6

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Product name:(2R,4R,5R)-1-(Benzyloxy)-5-hydroxy-2,4-dimethylheptan-3-one

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